Creative Biolabs offers engineered protein scaffold library construction service. Our service has provided a strong foundation for the successful isolation and exploitation of high-affinity binders in the fields of research, diagnosis, and therapy. Creative Biolabs has developed trimer codon technology, which offers site-directed mutant library construction in a high-throughput and extremely precise way.

Engineered protein scaffolds are invaluable tools for a vast range of biotechnological and pharmaceutical applications. Possibilities of engineered protein scaffolds have been explored in research, diagnostics and therapy in the last few years. Some scaffolds have focused on broadening their fields of application, while others have occupied their respective niche. The modular structure of these protein scaffolds and their favorable biophysical & chemical properties, such as small in size, high permeability through the cell membrane, lack of disulfide bonds within the molecule, high thermodynamic stability and lack of aggregation, not only allow the binding of a diverse set of targets in a specific manner and with high affinity, but also suggest the utilization of the rigid protein framework for generic engineering concepts, intracellular applications, for instance. By now, reports on the utilization of the engineered protein scaffolds have expanded to X-ray structure determination of binder/target complexes, imaging of cell surface markers and conjugation with drug payloads. Notably, these are also the classes where members have progressed to clinical trials.