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CRC is the third most commonly diagnosed cancer with more than 1 million new cases annually and is responsible for the death of more than 500,000 people. CRC develops by the accumulation of mutations, starting in stem cells at the base of the crypts, and usually begins as a non-cancerous polyp. CRC incidence can be associated with several genetic factors such as germline mutations in the mismatch repair genes and adenomatous polyposis coli (APC) gene. In addition to genetic predispositions, environmental factors such as lifestyle and diet play an important role in CRC risk. This lifestyle and diet lead to disturbances in the intestinal environment, including the luminal content and microbiota. The microbiota plays a role in generating biochemical and physiological conditions that may increase the number of colonic pre-neoplastic lesions. Modulation of the unbalanced gut microbiota can reduce the risk of colon cancer risk. Learn more: colorectal cancer probiotics

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