The synthesis of the ribosome is a highly ordered cellular process that requires a substantial expenditure of energy. Under stress situations, with decreased ribosome activity, protein synthesis was reduced, and subsequent growth was arrested. Thus, the relative abundance of ribosomal proteins reflects the rate of ribosome biogenesis, which is a critical element involved in controlling cell growth and proliferation. Several human diseases have been demonstrated to be associated with defects in ribosome biogenesis, including increased cancer susceptibility. Therefore, the relative abundance of ribosomal proteins has been regarded as a potential biomarker for many related diseases.