Non-IgG Antibody Related Diseases {{ currentPage ? currentPage.title : "" }}

IgA mostly originates from gut B cell responses to commensals, and IgA responses develop through highly complementary T cell-independent (TI) and T cell-dependent (TD) pathways. While TI-induced IgA broadly targets non-invasive commensals, TD-induced IgA coats penetrant commensals, and invasive pathogens. IgA can be detected in both gut mucosa and serum. In humans, intestinal IgA is dimeric, whereas serum IgA is largely monomeric. Intraluminal IgA, called secretory IgA (SIgA), further includes a pIgR-derived fragment termed the secretory component. This polypeptide covalently binds to SIgA to augment its stability and provide mucus-anchoring sites. Based on its characteristics, there are many diseases related to IgA, such as IgA nephropathy, dermatitis herpetiformis, celiac disease, inflammatory bowel disease (IBD), bullous disease, liver diseases, and sjögren's syndrome. Learn more: Non-IgG Antibody Related Diseases

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